Yes! Dissociation should always be highest at the working cells and lowest at the lungs. So, if temperature is increased in the working cells because ATP is being broken down for energy, then it would be logical that increased temperature would lead to increased dissociation. And physiology is extremely logical. If it makes sense, your body is probably designed to do it. That's the case with each factor affecting Hb-O2 dissociation. Click Next.